Development and evaluation of everolimus fast dissolving tablets

Abstract

Recent developments in Fast Dissolving tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the Fast Dissolving tablets of Everolimus, It is currently used as an immunosuppressant to prevent rejection of organ transplants and in the treatment of renal cell cancer and other tumours. Hence, the present investigation was undertaken with a view to develop a Fast Dissolving tablet of Everolimus which offers a new range of products having desired characteristics and intended benefits. Super disintegrants such as Ac-Di-Sol was used. Drug-excipient compatibility studies were carried. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, disintegration time, and uniformity of content and in vitro dissolution. It was concluded that Fast Dissolving tablets of Everolimuswere formulated successfully with desired characteristics which disintegrated rapidly and enhanced the patient convenience and compliance.