Formulation And Evaluation Of Orodispersible Tablets Incorporating Zidovudine Utilizing Natural Superdisintegrants

Abstract

ODTs are patient-friendly dose forms that quickly disintegrate in the mouth without water. Nine ODT zidovudine antiretroviral medication formulations were produced in this study utilising different natural superdisintegrant. The solubility and dissolving rate of the therapeutic molecules used in this study were improved by using starch tartrate, sodium starch glycolate, and croscarmellose sodium as super disintegrating agents. The formulations were all made utilizing 16-station rotary tablet punching machine and the direct compression method. The next step was to compress the improved mixture into tablets and test their solubility in a controlled laboratory setting. The combination of formulations exhibited favorable flow characteristics, including depth of repose, tapped density, and bulk density. The produced tablets passed all quality control assessment criteria according to I.P. limits and demonstrated good post-compression parameters. Formulation ZF3 was determined to be the most effective since it released the most medicine (100.05 percent) in the shortest duration of time (15 minutes). With a dosage of 75 mg, the ZF3 formulation includes starch tartrate (ST) as a super disintegrant.