Formulation And Evaluation Of Neomycin Sulfate Loaded Transferosomes Gel For Topical Use

Authors

  • Umamaheswari.D Assistant Professor, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai, Tamilnadu, India.
  • Senthil Prabhu. R Assistant Professor, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai, Tamilnadu, India.
  • Balaji. R PG Scholar, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai, Tamilnadu, India.
  • Sheik Abdulla Kapoor M PG Scholar, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai, Tamilnadu, India.
  • Vinodha.G PG Scholar, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai, Tamilnadu, India.
  • Ponraj. S PG Scholar, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai, Tamilnadu, India.
  • Karolin Shalima. A PG Scholar, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai, Tamilnadu, India.

Keywords:

Carbopol 940, Entrapment Efficiency, Neomycin Sulfate, Transferosomes

Abstract

Neomycin Sulfate is an aminoglycoside antibiotic used to treat bacterial skin infections. Neomycin Sulfate transferosomes were prepared using the thin lipid film hydration technique. The prepared transferosomes demonstrated high drug entrapment efficiency (EE), ranging from 39.07% to 85.03%, with small particle sizes between 445 nm and 592 nm. The optimized Neomycin Sulfate transferosomes formulation was incorporated into a Carbopol 940 gel base and evaluated for appearance, clarity, pH, drug content, and in vitro activity. The in vitro release study indicated an inverse relationship between entrapment efficiency and drug releases. Over 12 hours of studies, the drug release ranged from 69.74% to 83.68%. Kinetic analysis of the optimized formulation's release profiles followed the Korsmeyer-Peppas model, with the highest correlation coefficient (R² = 0.9983) for the optimized TF3 formulation. The value of "n" was calculated as 0.9683 which indicates that the drug release from the polymeric matrix followed a non-Fickian transport mechanism. These findings underscore the promise of Neomycin Sulfate-loaded transferosomes gel as an innovative drug delivery system for treating skin conditions. 

Dimensions

Published

2025-02-03